ea0073oc5.5 | Oral Communications 5: Thyroid | ECE2021
Pecce Valeria
, Abballe Luana
, Sponziello Marialuisa
, Brunelli Chiara
, Verrienti Antonella
, Annunziata Salvatore
, Grani Giorgio
, Fadda Guido
, Salvatori Massimo
, Russo Diego
, Durante Cosimo
Radioiodide 131I (RAI) is the therapy of choice for radioiodine-avid differentiated thyroid cancer (DTC). However, 515% of DTC patients become RAI refractory (RAIR), and the 10-year survival rate for metastatic disease decreases to 10%. The failure of RAI response is mainly due to the loss of thyroid differentiation, that leads to the loss of expression/function of components of iodide metabolism, first of all the Na/I symporter (NIS). The finding that the MAPK pathway i...